Mechanism of Action PDF Print E-mail
PS (in green) is a molecule normally located inside all cells where it's kept inactive
The cancer microenvironment causes PS to flip to the outside of cells lining tumor blood vessels. Chemotherapy further increases exposed PS in the tumor environment
Exposed PS is a highly immunosuppressive molecule that mimics "apoptosis", muting immune responses
Bavituximab (yellow) overrides PS-mediated immunosuppressive signals...
allowing immune reactivation to attack the tumor
Activated immune system causes tumor blood flow shut down and adaptive immune response to the tumor

 

Read more about bavituximab’s broad therapeutic potential

Clinical data on Bavituximab
 
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