Recent Preclinical Data Expand Bavituximab's Therapeutic and Imaging Potential

Bavituximab and other PS-targeting antibodies have shown consistently encouraging signs of anti-tumor activity in multiple preclinical studies including models of lung, pancreatic, breast, prostate and brain cancer. Additionally, experimental cancer vaccine regimens utilizing bavituximab have demonstrated the potential to generate protective immune responses against specific tumor challenges. Recent studies have also identified multiple immuno-stimulatory mechanisms induced by bavituximab and other PS-targeting antibodies that likely contribute to their observed anti-tumor effects.

PS-Targeting Antibodies Show Broad Potential to Image Tumors and Assess Cancer Therapy Response

2011 World Molecular Imaging Congress Poster Presentations

• Imaging of Human Tumor Xenografts in Mice Using Near-Infrared Fluorescent-Labeled Phosphatidylserine Targeting Antibodies View poster...

• Multimodal Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model View poster...

Broad-Spectrum Therapeutic and Diagnostic Potential Highlighted at the American Association of Cancer Research (AACR) Annual Meeting

2011 AACR Poster Presentations:

• Prostate Cancer: Targeting Phosphatidylserine to Improve Hormone Therapy of Prostate Cancer. View poster...

• Advanced Liver Cancer: Phosphatidylserine-Targeting Antibody Combined with Sorafenib has Strong Anti-Tumor Activity Against Human Hepatocellular Carcinomas in Mice. View poster...

• Mechanism of Action: Phosphatidylserine-Targeting Antibody Induces Differentiation of Myeloid-Derived Suppressor Cells into M1-Like Macrophages. View poster...

• Prostate Cancer: PS-Targeting Antibody Enhances Survival Benefit of Androgen Deprivation Therapy of Mice Bearing Syngeneic Prostate Cancer. View poster...

2010 AACR Poster Presentations:

• Mechanism of Action: Phosphatidylserine on Dying Tumor Cells Suppresses Dendritic Cell Activation and Inhibits Tumor Immunity: Reversal with PS-Targeting Antibody. View poster...
• Imaging: Phosphatidylethanolamine is a marker of tumor vasculature and can be used as a target for optical imaging. View poster...

Bavituximab in Action Experiments in animals have shown that bavituximab recruits immune cells into the tumor environment.
Before Therapy	After Therapy
Key Blue: tumor cell nuclei Red: blood vessels Green: immune cells (macrophages)

Read about the growing body of published research validating bavituximab’s broad-spectrum potential...