PS-Targeted Imaging Data

The utility of our PS-targeting antibodies as imaging agents has been established through multiple preclinical studies. For details, please see the following posters and peer reviewed publications:

Posters

• Tumor detection and measurement of responses to chemotherapy using human phosphatidylserine targeting antibody fragments
• Multimodal Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model
• Imaging of Human Tumor Xenografts in Mice Using Near-Infrared Fluorescent- Labeled Phosphatidylserine-Targeting Antibodies
• Monitoring Tumor Response to Chemotherapy by In Vivo Real-time Imaging of Phosphatidylserine Targeting Antibodies
• Phosphatidylethanolamine is a marker of tumor vasculature and can be used as a target for optical imaging

Publications

• Measuring Response to Therapy By Near-infrared Imaging of Tumors Using A Phosphatidylserine-targeting Antibody Fragment. Jian Gong, Richard Archer, Michael Brown, Seth Fisher, Connie Chang, Matthew Peacock, Christopher Hughes, Bruce Freimark, Molecular Imaging - Volume 12, Number 4 June 2013, 12, 1536-0121
• Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic- Labeled Antibody that Binds Exposed Phosphatidylserine. Marc Jennewein, Matthew A. Lewis, Dawen Zhao, et al., Clinical Cancer Research 2008;14:1377-1385
• Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Dawen Zhao, Jason H. Stafford†, Heling Zhou and Philip E. Thorpe, Translational Oncology, Volume 4, Number 6, December 2011, pp. 355–364
• An Orthotopic Lung Tumor Model for Image-Guided Microirradiation in Rats. Debabrata Saha, Linda Watkins, Yi Yin, Philip Thorpe, Michael D. Story, Kwang Song, Pavithra Raghavan, Robert Timmerman, Benjamin Chena, John D. Minna, and Timothy D. Solberg, Radiation Research 2010 July ; 174(1): 62–7
• Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium. Jason H. Stafford and Philip E. Thorpe, Neoplasia, Volume 13, Number 4 April 2011, pp. 299–308