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Our PS-targeting and TNT technologies are supported by extensive published research. For additional information, please reference:
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PS-Targeting Oncology Publications
- Brendan F. Judy, Louis A. Aliperti, Jarrod D. Predina, Daniel Levine, Veena Kapoor, Philip E. Thorpe, Steven M. Albelda and Sunil Singhal, Vascular Endothelial–Targeted Therapy Combined with Cytotoxic Chemotherapy Induces Inflammatory Intratumoral Infiltrates and Inhibits Tumor Relapses after Surgery, Neoplasia: 2012, Volume 14, Number 4
- David E. Gerber, Alison T. Stopeck, Lucas Wong, Lee S. Rosen, Philip E. Thorpe, Joseph S. Shan, and Nuhad K. Ibrahim, Phase I Safety and Pharmacokinetic Study of Bavituximab, a Chimeric Phosphatidylserine-Targeting Monoclonal Antibody, in Patients with Advanced Solid Tumors, Clinical Cancer Research: 2011, 11-1074
- Paul DeRose, Philip E. Thorpe & David E Gerber, Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment. Immunotherapy: 2011, Vol. 3, No. 8, Pages 933-944
- Xianming Huang, Dan Yea and Philip E. Thorpe, Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine. Vaccine: 2011, doi:10.1016/j.vaccine.2011.04.082
- Hogg, R.T., Thorpe, P.E., Gerard, R.D., Retargeting adenoviral vectors to improve gene transfer into tumors, Cancer Gene Therapy: 2010, doi: 10.1038/cgt.2010.78
- Liang, Y., Besch-Williford, C., Benakanakere, I., Thorpe, P.E., and Salman M. Hyder, Targeting mutant p53 protein and the tumor vasculature: an effective combination therapy for advanced breast tumors. Breast Cancer Research and Treatment: 2010, Volume 125, Number 2, 407-420
- Thorpe, P.E., Targeting anionic phospholipids on tumor blood vessels and tumor cells. Thrombosis Research 2010, Apr;125 Suppl 2:S134-7
- He, J. Thorpe, P.E., et al, Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma. Clinical Cancer Research, 2009, 15(22):6871–80
- Marconescu A, Thorpe P.E., Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochemica et Biophysica Acta 2008, 1778(10):2217-24
- Jennewein M., Thorpe, P.E., et al, Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine. Clinical Cancer Research, 2008, 14(5):1377-85
- He, J. Luster, T., Thorpe, P.E., Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids. Clinical Cancer Research, 2007, 13, 5211
- Beck, A.W., Thorpe, P.E., et al, Combination of a monoclonal antiphosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. International Journal of Cancer, 2005, Volume 118 Issue 10, 2639 - 2643
- Huang, X., Thorpe, P.E., et al, A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice. Cancer Research 2005, 65, 4408-4416
- Ran, S., Thorpe, P.E., et al, Antitumor Effects of a Monoclonal Antibody that Binds Anionic Phospholipids on the Surface of Tumor Blood Vessels in Mice. Clinical Cancer Research 2005, Vol. 11, 1551-1562
- Ran, S., Thorpe, P.E., et al, Increased Exposure of Anionic Phospholipids on the Surface of Tumor Blood Vessels. Cancer Research 2002, 62, 6132-6140
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PS-Targeting Imaging Publications
- Measuring Response to Therapy By Near-infrared Imaging of Tumors Using A Phosphatidylserine-targeting Antibody Fragment. Jian Gong, Richard Archer, Michael Brown, Seth Fisher, Connie Chang, Matthew Peacock, Christopher Hughes, Bruce Freimark, Molecular Imaging - Volume 12, Number 4 June 2013, 12, 1536-0121
- Vascular Imaging of Solid Tumors in Rats with a Radioactive Arsenic- Labeled Antibody that Binds Exposed Phosphatidylserine. Marc Jennewein, Matthew A. Lewis, Dawen Zhao, et al., Clinical Cancer Research 2008;14:1377-1385
- Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model. Dawen Zhao, Jason H. Stafford†, Heling Zhou and Philip E. Thorpe, Translational Oncology, Volume 4, Number 6, December 2011, pp. 355–364
- An Orthotopic Lung Tumor Model for Image-Guided Microirradiation in Rats. Debabrata Saha, Linda Watkins, Yi Yin, Philip Thorpe, Michael D. Story, Kwang Song, Pavithra Raghavan, Robert Timmerman, Benjamin Chena, John D. Minna, and Timothy D. Solberg, Radiation Research 2010 July ; 174(1): 62–7
- Increased Exposure of Phosphatidylethanolamine on the Surface of Tumor Vascular Endothelium. Jason H. Stafford and Philip E. Thorpe, Neoplasia, Volume 13, Number 4 April 2011, pp. 299–308
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PS-Targeting Antiviral Publications
- Moody, M.A., Haynes, B.F., et al, Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines. The Journal of Experimental Medicine, 2010, vol. 207 no. 4 763-776
- Soares MM, King SW, Thorpe PE, Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases. Nature Medicine 2008 Dec;14(12):1357-62
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Cotara Publications
- Sloan, A.E., Hdeib, A. Convection-enhanced delivery of 131I-chTNT-1/B mAB for treatment of high-grade adult gliomas. Expert Opinion on Biological Therapy, 2011, doi:10.1517/14712598.2011.579097
- Jensen, R. et al, Clinical Update: Treatment of Glioblastoma Multiforme with Radiolabeled Antibodies that Target Tumor Necrosis, Current Cancer Therapy Reviews, 2010, Volume 6, Number 1, February 2010 , pp. 13-18
- Shapiro, W.R., Shan, J.S., et al, 2006. (131)I-chTNT-1/B mAb: tumor necrosis therapy for malignant astrocytic glioma. Expert Opinion on Biological Therapy, 2006, 6 (5):539-45
- Patel, S.J., Shan, J.S., et al, Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients. Neurosurgery, 2005, Jun;56(6):1243-52; discussion 1252-3.
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