PS-Targeting Oncology Publications

• David E. Gerber, Alison T. Stopeck, Lucas Wong, Lee S. Rosen, Philip E. Thorpe, Joseph S. Shan, and Nuhad K. Ibrahim, Phase I Safety and Pharmacokinetic Study of Bavituximab, a Chimeric Phosphatidylserine-Targeting Monoclonal Antibody, in Patients with Advanced Solid Tumors, Clinical Cancer Research: 2011, 11-1074
• Paul DeRose, Philip E. Thorpe & David E Gerber, Development of bavituximab, a vascular targeting agent with immune-modulating properties, for lung cancer treatment. Immunotherapy: 2011, Vol. 3, No. 8, Pages 933-944
• Xianming Huang, Dan Yea and Philip E. Thorpe, Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine. Vaccine: 2011, doi:10.1016/j.vaccine.2011.04.082
• Hogg, R.T., Thorpe, P.E., Gerard, R.D., Retargeting adenoviral vectors to improve gene transfer into tumors, Cancer Gene Therapy: 2010, doi: 10.1038/cgt.2010.78
• Liang, Y., Besch-Williford, C., Benakanakere, I., Thorpe, P.E., and Salman M. Hyder, Targeting mutant p53 protein and the tumor vasculature: an effective combination therapy for advanced breast tumors. Breast Cancer Research and Treatment: 2010, Volume 125, Number 2, 407-420
• Thorpe, P.E., Targeting anionic phospholipids on tumor blood vessels and tumor cells. Thrombosis Research 2010, Apr;125 Suppl 2:S134-7
• He, J. Thorpe, P.E., et al, Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma. Clinical Cancer Research, 2009, 15(22):6871–80
• Marconescu A, Thorpe P.E., Coincident exposure of phosphatidylethanolamine and anionic phospholipids on the surface of irradiated cells. Biochemica et Biophysica Acta 2008, 1778(10):2217-24
• Jennewein M., Thorpe, P.E., et al, Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine. Clinical Cancer Research, 2008, 14(5):1377-85
• He, J. Luster, T., Thorpe, P.E., Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids. Clinical Cancer Research, 2007,  13, 5211
• Beck, A.W., Thorpe, P.E., et al, Combination of a monoclonal antiphosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice. International Journal of Cancer, 2005, Volume 118 Issue 10, 2639 - 2643
• Huang, X., Thorpe, P.E., et al, A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice. Cancer Research 2005, 65, 4408-4416
• Ran, S., Thorpe, P.E., et al, Antitumor Effects of a Monoclonal Antibody that Binds Anionic Phospholipids on the Surface of Tumor Blood Vessels in Mice. Clinical Cancer Research 2005, Vol. 11, 1551-1562
• Ran, S., Thorpe, P.E., et al, Increased Exposure of Anionic Phospholipids on the Surface of Tumor Blood Vessels. Cancer Research 2002, 62, 6132-6140